Triadimefon

Triadimefon is a fungicide used in agriculture to control various fungal diseases. As a seed treatment, it is used on barley, corn, cotton, oats, rye, sorghum, and wheat.^[2] In fruit it is used on pineapple and banana.^[2] Non-food uses include pine seedlings, Christmas trees, turf, ornamental plants, and landscaping.^[2]

Triadimefon

Names
IUPAC name 1-(4-Chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one
Other names Triadimeform, Strike, Miltek, Nurex, Reach.
Identifiers
CAS Number	43121-43-3 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:9665 Y
ChemSpider	36029
ECHA InfoCard	100.050.986
PubChem CID	39385
UNII	1HW039CJF0 Y
CompTox Dashboard (EPA)	DTXSID3023897
InChI InChI=1S/C14H16ClN3O2/c1-14(2,3)12(19)13(18-9-16-8-17-18)20-11-6-4-10(15)5-7-11/h4-9,13H,1-3H3 Key: WURBVZBTWMNKQT-UHFFFAOYSA-N InChI=1/C14H16ClN3O2/c1-14(2,3)12(19)13(18-9-16-8-17-18)20-11-6-4-10(15)5-7-11/h4-9,13H,1-3H3 Key: WURBVZBTWMNKQT-UHFFFAOYAV
SMILES CC(C)(C)C(=O)C(N1C=NC=N1)OC2=CC=C(C=C2)Cl
Properties
Chemical formula	C14H16ClN3O2
Molar mass	293.75 g·mol−1
Density	1.22 g/cm3[1]
Melting point	82 °C (180 °F; 355 K)[1]
Boiling point	decomposes
Solubility in water	64 mg/L (20 °C)[1]
Hazards
Lethal dose or concentration (LD, LC):
LD50 (median dose)	363 mg/kg (oral, rat)[1] > 5000 mg/kg (dermal, rat)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Pharmacology

Estrogenic effect, inhibition of aromatase activity, decrease of estrogens production and increase androgens availability.^[3]

Triadimefon potently inhibited rat’s neurosteroidogenic enzymes, 5α-Red1 and 3α-HSD.^[4]

Dopamine as well as serotonergic pathways are involved.^[5][6]

Psychomotor stimulatory.^[7] Anti-estrogen effect.^[8]