Tribendimidine

Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.^[1]

Tribendimidine

Clinical data
ATC code	none
Identifiers
IUPAC name N,N-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4 -phenylene dimethylidyneamine
CAS Number	115103-15-6 N
PubChem CID	3086564
ChemSpider	2343161 Y
UNII	YO6SOD6ZTJ
ChEMBL	ChEMBL427256 N
CompTox Dashboard (EPA)	DTXSID50894077
Chemical and physical data
Formula	C28H32N6
Molar mass	452.606 g·mol−1
3D model (JSmol)	Interactive image
SMILES N(=C/c2ccc(\C=N\c1ccc(/N=C(/N(C)C)C)cc1)cc2)\c3ccc(\N=C(\N(C)C)C)cc3
InChI InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3/b29-19+,30-20+,31-21+,32-22+ Y Key:XOIOGKHKNQYULW-HTNNXBMUSA-N Y
NY (what is this?)  (verify)

In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.^[2] It is also effective against clonorchiasis.^[3] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.^[1] The drug has also performed well in trials against opisthorchiasis, curing about 70% of cases.^[4]

Tribendimidine is manufactured by Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China. It was approved by the China Food and Drug Administration in 2007.^{[citation needed]}