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Trimeric intracellular cation-selective channel
Protein From Wikipedia, the free encyclopedia
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The trimeric intracellular cation-selective channels or TRIC proteins are a group of homo-trimeric cation channel proteins of ~300 residues in the ER membrane.[1] There are two known TRIC proteins, TRIC-A and TRIC-B.
Channel function
TRICs are permeable to both Na+ and K+ but not divalent cations like Ca2+.[1] They exhibit marked voltage-dependence, becoming more open when the cytosol is more positively charged than the ER lumen.
TRIC-A
TRIC-A is predominantly expressed in excitable tissues including brain and skeletal muscle.[1] TRIC-A activity is thought to support RyR1-mediated efflux of Ca2+ ions from the sarcoplasmic reticulum into the cytosol.
TRIC-B
K+ flux into the ER through TRIC-B is thought to support IP3-induced efflux of Ca2+ ions through IP3-gated Ca2+ channels in the ER membrane.
Clinical significance
TRIC-A has been implicated in the regulation of arterial blood pressure through regulating the excitability of vascular smooth muscle cells.[1] Several single-nucleotide polymorphisms (SNPs) in close proximity to the TRIC-A locus and, in future, may serve as an important biomarker in the diagnosis of essential hypertension [1]
Null mutations in TMEM38B encoding TRIC-B are an uncommon but relatively severe cause of autosomal recessive osteogenesis imperfecta or "brittle bone disease".[2]
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References
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