Triphenylmethylethylene

Triphenylmethylethylene, also known as methyltriphenylethylene or as triphenylpropene, is a synthetic nonsteroidal estrogen of the triphenylethylene group that is related to triphenylchloroethylene and was never marketed.^[1][2] Along with diethylstilbestrol and triphenylchoroethylene, triphenylmethylethylene was studied in 1944 by Sir Alexander Haddow for the treatment of breast cancer, and this is historically notable in that it was the first time that high-dose estrogens were found to be effective in the treatment of breast cancer.^[1][3] However, while diethylstilbestrol and triphenylchloroethylene were found to be significantly effective, triphenylmethylethylene was less effective and showed a favorable response in only 1 of 4 treated cases.^[4][5]

Triphenylmethylethylene

Clinical data
Other names	Methyltriphenylethylene; Triphenylpropene
Drug class	Nonsteroidal estrogen
Identifiers
IUPAC name 1,1-diphenylprop-1-en-2-ylbenzene
CAS Number	3677-70-1
PubChem CID	4207747
ChemSpider	3417659
UNII	92DB2Q7TH8
CompTox Dashboard (EPA)	DTXSID601337056
Chemical and physical data
Formula	C21H18
Molar mass	270.375 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=C(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3
InChI InChI=1S/C21H18/c1-17(18-11-5-2-6-12-18)21(19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16H,1H3 Key:FLTIZNYOOOPPHQ-UHFFFAOYSA-N

See also

• Triphenylbromoethylene
• Triphenyliodoethylene