Tryptophan N-monooxygenase

Tryptophan N-monooxygenase (EC 1.14.13.125, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating).^[1][2][3][4] This enzyme catalyses the following chemical reaction

L-tryptophan + 2 O₂ + 2 NADPH + 2 H⁺ ${\displaystyle \rightleftharpoons }$ (E)-indol-3-ylacetaldoxime + 2 NADP⁺ + CO₂ + 3 H₂O (overall reaction)

(1a) L-tryptophan + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ N-hydroxy-L-tryptophan + NADP⁺ + H₂O

(1b) N-hydroxy-L-tryptophan + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ N,N-dihydroxy-L-tryptophan + NADP⁺ + H₂O

(1c) N,N-dihydroxy-L-tryptophan ${\displaystyle \rightleftharpoons }$ (E)-indol-3-ylacetaldoxime + CO₂ + H₂O

Tryptophan N-monooxygenase
Identifiers
EC no.	1.14.13.125
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Tryptophan N-monooxygenase is a heme-thiolate protein (P-450).