Tuberous sclerosis complex tumor suppressors

For the genetic disease, see Tuberous sclerosis.

Tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 molecular complex. Under poor growth conditions the TSC1-TSC2 complex limits cell growth.^[1] A key promoter of cell growth, mTORC1, is inhibited by the tuberous sclerosis complex.^[1] Insulin activates mTORC1 and causes dissociation of TSC from the surface of lysosomes.^[2]

Resistance to ischemia-reperfusion injury by protein restriction is mediated by activation of the tuberous sclerosis complex.^[3]