Tyrosine N-monooxygenase

Tyrosine N-monooxygenase (EC 1.14.13.41, tyrosine N-hydroxylase, CYP79A1) is an enzyme with systematic name L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating).^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

L-tyrosine + 2 O₂ + 2 NADPH + 2 H⁺ ${\displaystyle \rightleftharpoons }$ (Z)-[4-hydroxyphenylacetaldehyde oxime] + 2 NADP⁺ + CO₂ + 3 H₂O (overall reaction)

(1a) L-tyrosine + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ N-hydroxy-L-tyrosine + NADP⁺ + H₂O

(1b) N-hydroxy-L-tyrosine + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ N,N-dihydroxy-L-tyrosine + NADP⁺ + H₂O

(1c) N,N-dihydroxy-L-tyrosine ${\displaystyle \rightleftharpoons }$ (Z)-[4-hydroxyphenylacetaldehyde oxime] + CO₂ + H₂O

Tyrosine N-monooxygenase
Identifiers
EC no.	1.14.13.41
CAS no.	159447-19-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Tyrosine N-monooxygenase is heme-thiolate protein (P-450).