U-50488

U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects.^[1] It has analgesic, diuretic and antitussive effects,^[2] and reverses the memory impairment produced by anticholinergic drugs.^[3] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.^[4][5] This compound has never received FDA approval and there are no reported human cases in the literature involving an U-50488 overdose.^[6]

U-50488

Identifiers
IUPAC name 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
CAS Number	67198-13-4 Y
PubChem CID	3036289
IUPHAR/BPS	1652
ChemSpider	2300345 N
UNII	39K8JHE8XN
ChEBI	CHEBI:73358 N
ChEMBL	ChEMBL441765 N
CompTox Dashboard (EPA)	DTXSID60953023
Chemical and physical data
Formula	C19H26Cl2N2O
Molar mass	369.33 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1 N Key:VQLPLYSROCPWFF-QZTJIDSGSA-N N
NY (what is this?)  (verify)

See also

• LPK-26
• U-47700
• U-69,593