U-69,593

U-69,593 is a drug which acts as a potent and selective κ₁-opioid receptor agonist.^[1][2][3] In animal studies it has been shown to produce antinociception,^[1][4][5] anti-inflammation,^[6] anxiolysis (at low doses),^[7][8][9] respiratory depression,^[5] and diuresis,^[10] while having little effect on gastrointestinal motility.^[1] It also inhibits the peripheral, though not central secretion of oxytocin and vasopressin in rats.^[11][12]

U-69,593

Clinical data
ATC code	none
Identifiers
IUPAC name N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide
CAS Number	96744-75-1
PubChem CID	105104
IUPHAR/BPS	1655
ChemSpider	94828
UNII	J5S4K6TKTG
ChEBI	CHEBI:73357 Y
ChEMBL	ChEMBL440765
CompTox Dashboard (EPA)	DTXSID3046326
Chemical and physical data
Formula	C22H32N2O2
Molar mass	356.510 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N([C@H]3CC[C@]1(OCCC1)C[C@@H]3N2CCCC2)C)Cc4ccccc4

See also

• U-50,488
• The dichloro analog is called spiradoline.