U7 small nuclear RNA

The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.

U7 small nuclear RNA
Predicted secondary structure and sequence conservation of U7
Identifiers
Symbol	U7
Rfam	RF00066
Other data
RNA type	Gene; snRNA
Domain(s)	Eukaryota
SO	SO:0000274
PDB structures	PDBe

The 5' end of the U7 snRNA binds the HDE (histone downstream element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site.^[1][2] The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.^[3]

See also

• Duchenne muscular dystrophy
• Histone 3' UTR stem-loop
• LSM10