Ubiquilin 4

Ubiquilin 4 is a protein in humans that is encoded by the UBQLN4 gene.^[5][6][7] Ubiquilin 4 regulates proteasomal protein degradation.^[8]

UBQLN4
Identifiers
Aliases	UBQLN4, A1U, A1Up, C1orf6, CIP75, UBIN, Ubiquilin 4
External IDs	OMIM: 605440; MGI: 2150152; HomoloGene: 41346; GeneCards: UBQLN4; OMA:UBQLN4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,035,299 bp[1] End 156,053,798 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,461,065 bp[2] End 88,477,032 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone gastrocnemius muscle right frontal lobe cingulate gyrus anterior cingulate cortex caudate nucleus putamen prefrontal cortex tibialis anterior muscle Top expressed in ventricular zone muscle of thigh superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex epiblast skeletal muscle tissue yolk sac triceps brachii muscle lip More reference expression data BioGPS n/a
Gene ontology Molecular function polyubiquitin modification-dependent protein binding protein binding identical protein binding Cellular component cytoplasm perinuclear region of cytoplasm autophagosome nuclear proteasome complex cytosolic proteasome complex cytosol endoplasmic reticulum membrane cytoplasmic vesicle endoplasmic reticulum nucleus chromosome site of DNA damage Biological process autophagy negative regulation of autophagosome maturation regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process DNA repair cellular response to DNA damage stimulus negative regulation of double-strand break repair via homologous recombination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56893 94232 Ensembl ENSG00000160803 ENSMUSG00000008604 UniProt Q9NRR5 Q99NB8 RefSeq (mRNA) NM_001304342 NM_020131 NM_033526 RefSeq (protein) NP_001291271 NP_064516 NP_277068 Location (UCSC) Chr 1: 156.04 – 156.05 Mb Chr 3: 88.46 – 88.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Similarity to Other Proteins

Human UBQLN4 shares a high degree of similarity with related ubiquilins including UBQLN1 and UBQLN2.^[9]