UGT2B4

UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene.^[5][6][7]

UGT2B4
Identifiers
Aliases	UGT2B4, HLUG25, UDPGT2B4, UDPGTH1, UDPGTh-1, UGT2B11, UDP glucuronosyltransferase family 2 member B4
External IDs	OMIM: 600067; MGI: 1919023; HomoloGene: 130717; GeneCards: UGT2B4; OMA:UGT2B4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 69,480,165 bp[1] End 69,526,014 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 87,064,497 bp[2] End 87,074,389 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver gonad testicle left ventricle right auricle of heart right ventricle myocardium islet of Langerhans myocardium of left ventricle Top expressed in left lobe of liver embryo lumbar subsegment of spinal cord right ventricle tibiofemoral joint sexually immature organism medial head of gastrocnemius muscle lumbar spinal ganglion stria vascularis carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity glucuronosyltransferase activity retinoic acid binding hexosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane organelle membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle endoplasmic reticulum membrane Biological process cellular glucuronidation metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7363 71773 Ensembl ENSG00000156096 ENSMUSG00000035836 UniProt P06133 Q8R084 RefSeq (mRNA) NM_001297615 NM_001297616 NM_021139 NM_152811 RefSeq (protein) NP_001284544 NP_001284545 NP_066962 NP_690024 Location (UCSC) Chr 4: 69.48 – 69.53 Mb Chr 5: 87.06 – 87.07 Mb PubMed search [3] [4]
Wikidata
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Function

UGT2B4 is mainly involved in the glucuronidation of hyodeoxycholic acid, a bile acid, and catechol-estrogens, such as 17-epiestriol and 4-hydroxy-estrone.^[8]

The expression of the UGT2B4 enzyme is upregulated by the farnesoid X receptor (FXR), a nuclear receptor which is activated by bile acids.^[9] These same bile acids are substrates for the UGT2B4 enzyme. Hence upregulation of UGT2B4 by activated FXR provides a mechanism for the detection, conjugation and subsequent elimination of toxic bile acids.