UH-232

UH-232 ((+)-UH232) is a drug which acts as a subtype selective mixed agonist-antagonist for dopamine receptors, acting as a weak partial agonist at the D₃ subtype,^[1] and an antagonist at D₂Sh autoreceptors on dopaminergic nerve terminals.^[2][3][4] It causes dopamine release in the brain and has a stimulant effect,^[5][6][7] as well as blocking the behavioural effects of cocaine.^[8] It may also serve as a 5-HT_2A receptor agonist, based on animal studies.^[9] It was investigated in clinical trials for the treatment of schizophrenia, but unexpectedly caused symptoms to become worse.^[9]

UH-232

Clinical data
ATC code	none
Identifiers
IUPAC name (1S,2R)-5-Methoxy-1-methyl-2-(N,N-propylamino)tetralin
CAS Number	95999-12-5 Y
PubChem CID	123696
UNII	QQYOR9S587
CompTox Dashboard (EPA)	DTXSID70875101
Chemical and physical data
Formula	C18H29NO
Molar mass	275.436 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC2C(N(CCC)CCC)CCc1c2cccc1OC
(verify)

(+)-AJ76

The N-monopropyl derivative (+)-AJ76 is an active metabolite of UH-232 and has practically identical effects.

(+)-AJ76, CAS# 85378-82-1, 13755572

See also

• 7-OH-DPAT
• Amisulpride
• DETQ
• RDS-127
• PNU-99,194
• Rotigotine
• UH-301