ULK2

Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene.^[1] The gene is located within the Smith–Magenis syndrome region on chromosome 17.

unc-51-like kinase 2 (C. elegans)
Identifiers
Symbol	ULK2
NCBI gene	9706
HGNC	13480
OMIM	608650
RefSeq	NM_014683
UniProt	Q8IYT8
Other data
EC number	2.7.11.1
Locus	Chr. 17 p11.2
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Structure and function

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain.^[2] ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.^[3]