Uroplakin-1a

Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.^[5][6][7]

UPK1A
Identifiers
Aliases	UPK1A, TSPAN21, UP1A, UPIA, UPKA, uroplakin 1A
External IDs	OMIM: 611557; MGI: 98911; HomoloGene: 21383; GeneCards: UPK1A; OMA:UPK1A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,666,517 bp[1] End 35,678,481 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B1|7 18.78 cM Start 30,302,517 bp[2] End 30,312,272 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad urinary bladder mucosa of urinary bladder vagina testicle skin of leg skin of abdomen urethra prostate oral cavity Top expressed in transitional epithelium of urinary bladder genital tubercle urethra morula right kidney tail of embryo left colon embryo salivary gland brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome apical plasma membrane endoplasmic reticulum membrane cell surface apical plasma membrane urothelial plaque Biological process cell surface receptor signaling pathway epithelial cell differentiation protein complex oligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11045 109637 Ensembl ENSG00000105668 ENSMUSG00000006313 UniProt O00322 Q9D132 RefSeq (mRNA) NM_007000 NM_001281443 NM_026815 RefSeq (protein) NP_001268372 NP_008931 NP_081091 Location (UCSC) Chr 19: 35.67 – 35.68 Mb Chr 7: 30.3 – 30.31 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins.

UP1a may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.^[7]