Uroplakin-3a

Uroplakin-3a (UP3a) is a protein that in humans is encoded by the UPK3A gene.^[5][6]

UPK3A
Identifiers
Aliases	UPK3A, UP3A, UPIII, UPIIIA, UPK3, uroplakin 3A
External IDs	OMIM: 611559; MGI: 98914; HomoloGene: 5066; GeneCards: UPK3A; OMA:UPK3A - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 45,284,949 bp[1] End 45,295,874 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E2 Start 84,901,342 bp[2] End 84,906,748 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle mucosa of urinary bladder monocyte prostate muscle of thigh granulocyte muscle of arm biceps brachii skeletal muscle tissue deltoid muscle Top expressed in transitional epithelium of urinary bladder Transitional epithelium of renal pelvis transitional epithelium of ureter medullary collecting duct male urethra epithelium of male urethra right kidney epithelium of female urethra morula embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component extracellular exosome endoplasmic reticulum membrane apical plasma membrane membrane integral component of membrane endoplasmic reticulum apical plasma membrane urothelial plaque Biological process kidney development urea transport epithelial cell differentiation sodium ion homeostasis potassium ion homeostasis urinary bladder development cell morphogenesis water transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7380 22270 Ensembl ENSG00000100373 ENSMUSG00000022435 UniProt O75631 Q9JKX8 RefSeq (mRNA) NM_001167574 NM_006953 NM_023478 RefSeq (protein) NP_001161046 NP_008884 NP_075967 Location (UCSC) Chr 22: 45.28 – 45.3 Mb Chr 15: 84.9 – 84.91 Mb PubMed search [3] [4]
Wikidata
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UP3a is found in the inner membrane of the urinary bladder and contributes to the strength of that membrane and to the membrane's ability to stretch when the bladder is full.^[7] It is also found in the renal pelvis, ureter, and prostatic urethra.