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Usona Institute
American non-profit medical research organization From Wikipedia, the free encyclopedia
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The Usona Institute is a 501(c)(3) non-profit medical research organization (MRO) which is developing psychedelic drugs for potential medical use.[2][1] It was launched by scientist and entrepreneur Bill Linton, who is the founder of the biotechnology company Promega Corporation, and by physician Malynn Utzinger in 2014.[2][1]
The organization is developing psilocybin (4-HO-DMT) for treatment of depression.[3][4] It started a phase 2 clinical trial of psilocybin for major depressive disorder in 2019.[2] The same year, this candidate received Food and Drug Administration (FDA) "breakthrough therapy" designation.[2][5] This clinical trial has since been completed and its psilocybin candidate is now in phase 3 clinical studies.[6][7] In July 2024, it was said that the Usona Institute was leading the largest clinical trial of ongoing psilocybin treatment for depression, a phase 3 trial with 240 participants treated with 5 or 25 mg psilocybin or placebo.[8] Other candidates of the institute include mebufotenin (5-MeO-DMT)[9] and bufotenin (5-HO-DMT),[10] among others.[11][12]
The Usona Institute is notable in manufacturing large quantities of synthetic psilocybin and supplying the drug for clinical trials throughout the world, which it does for free for research purposes.[2][13]
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