VLDLR-associated cerebellar hypoplasia

VLDLR-associated cerebellar hypoplasia (VLDLRCH) is a rare autosomal recessive condition caused by a disruption of the VLDLR gene.^[1][2] First described as a form of cerebral palsy in the 1970s,^[3] it is associated with parental consanguinity and is found in secluded communities, with a number of cases described in Hutterite families.^[4]

VLDLR-associated cerebellar hypoplasia
Other names	Dysequilibrium syndrome, DES; Nonprogressive cerebellar disorder with mental retardation)