SNF8

Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.^[5][6][7] It is a part of ESCRT-II complex.

SNF8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZME, 3CUQ
Identifiers
Aliases	SNF8, Dot3, EAP30, VPS22, ESCRT-II complex subunit, SNF8 subunit of ESCRT-II
External IDs	OMIM: 610904; MGI: 1343161; HomoloGene: 5239; GeneCards: SNF8; OMA:SNF8 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,929,316 bp[1] End 48,944,842 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.24 cM Start 95,925,711 bp[2] End 95,938,256 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart mucosa of transverse colon gastric mucosa stromal cell of endometrium left coronary artery ganglionic eminence right auricle of heart right adrenal gland popliteal artery tibial arteries Top expressed in embryo yolk sac morula dentate gyrus of hippocampal formation granule cell epiblast blastocyst right kidney superior frontal gyrus facial motor nucleus duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein N-terminus binding transcription factor binding protein C-terminus binding channel regulator activity protein binding Cellular component cytoplasm recycling endosome cytosol endosome membrane late endosome membrane transcription regulator complex plasma membrane nucleoplasm perinuclear region of cytoplasm endosome membrane extracellular exosome nucleus ESCRT II complex Biological process regulation of transcription, DNA-templated positive regulation of protein catabolic process multivesicular body sorting pathway regulation of transcription by RNA polymerase II multivesicular body assembly regulation of multivesicular body size involved in endosome transport transcription, DNA-templated endosomal transport regulation of protein complex stability positive regulation of gene expression early endosome to late endosome transport endocytic recycling regulation of protein catabolic process protein transport regulation of MAP kinase activity positive regulation of exosomal secretion protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway macroautophagy regulation of molecular function transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11267 27681 Ensembl ENSG00000159210 ENSMUSG00000006058 UniProt Q96H20 Q9CZ28 RefSeq (mRNA) NM_007241 NM_001317192 NM_001317193 NM_001317194 NM_033568 NM_001356362 RefSeq (protein) NP_001304121 NP_001304122 NP_001304123 NP_009172 NP_291046 NP_001343291 Location (UCSC) Chr 17: 48.93 – 48.94 Mb Chr 11: 95.93 – 95.94 Mb PubMed search [3] [4]
Wikidata
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