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VR-RNA

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In molecular biology, VR-RNA is a small RNA produced by Clostridium perfringens. It functions as a regulator of the two-component VirR/VirS system.[1][2]

VR-RNA regulates numerous genes including:

VR-RNA regulates the toxin colA (collagenase) by base-pairing to colA mRNA, the 3′ end of VR-RNA base-pairs to a region in the 5′UTR of the colA mRNA. This induces cleavage of the colA mRNA in the 5′ UTR and leads to stabilisation of the mRNA and increased translation.[17]

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