VU-0152100

VU-0152100 is a positive modulator of the M4 receptor,^[1] one of the muscarinic acetylcholine receptors.

VU-0152100

Names
IUPAC name 3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Identifiers
CAS Number	409351-28-6
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL1978713
ChemSpider	754902
ECHA InfoCard	100.209.922
EC Number	684-470-8
IUPHAR/BPS	3263
PubChem CID	864492
CompTox Dashboard (EPA)	DTXSID40357702
InChI InChI=1S/C18H19N3O2S/c1-10-8-11(2)21-18-14(10)15(19)16(24-18)17(22)20-9-12-4-6-13(23-3)7-5-12/h4-8H,9,19H2,1-3H3,(H,20,22) Key: MDNWGCQSCGNTKH-UHFFFAOYSA-N
SMILES CC1=CC(=NC2=C1C(=C(S2)C(=O)NCC3=CC=C(C=C3)OC)N)C
Properties
Chemical formula	C18H19N3O2S
Molar mass	341.43 g·mol−1
Hazards
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H301, H319
Precautionary statements	P264, P264+P265, P270, P280, P301+P316, P305+P351+P338, P321, P330, P337+P317, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Treatment of stimulant addiction

In mice, VU-0152100 is able to decrease self-administration of cocaine, this is thought to come from the M4 receptor's action on D1 containing dopaminergic neurons.^[2] It is also able to almost completely inhibit the hyperactivity caused by cocaine.^[3] Another study has shown that this drug is able to reverse hyperlocomotion induced by amphetamine, in an anti-psychotic-like manner.^[4] This data suggests that it could potentially be developed as a treatment for stimulant abuse.

See also

• VU-0152099