List of vaginal tumors

Vaginal tumors are neoplasms (tumors) found in the vagina. They can be benign or malignant.^[1][a] A neoplasm is an abnormal growth of tissue that usually forms a tissue mass.^[2][3][4] Vaginal neoplasms may be solid, cystic or of mixed type.^[5]

Vaginal cancers arise from vaginal tissue, with vaginal sarcomas develop from bone, cartilage, fat, muscle, blood vessels or other connective or supportive tissue.^[6][7] Tumors in the vagina may also be metastases (malignant tissue that has spread to the vagina from other parts of the body). ^[8][7] Cancer that has spread from the colon, bladder, and stomach is far more common than cancer that originates in the vagina itself.^[9] Some benign tumors may later progress to become malignant tumors, such as vaginal cancers.^[10][11] Some neoplastic growths of the vagina are sufficiently rare as to be only described in case studies.^[3]

Signs and symptoms may include a feeling of pressure, painful intercourse or bleeding.^[12] Most vaginal tumors are located during a pelvic exam. Ultrasonography, CT and MRI imaging is used to establish the location and presence or absence of fluid in a tumor.^[13][14] Biopsy provides a more definitive diagnosis.^[15]

Vaginal tumors

Micrograph showing the yolk sac component of a mixed germ cell tumour. H&E stain.

Micrograph of an H&E stained section of a peripheral PNET.

Blue nevus

Micrograph of a small-cell carcinoma showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin.

Micrograph of a mucinous adenocarcinoma

Micrograph of fibroepithelial polyp

Vaginal tumors	Benign	Synonyms and notes	References
Yolk sac tumor	no	Endodermal sinus tumor	[16][17][18][19][20][21][22]
Peripheral primitive neuroectodermal tumor	no	Ewing's sarcoma	[16][17][18][23]
Vaginal melanoma	no	Melanocytic tumor	[16][17][18][24][25]
Blue nevus	yes[26]	Melanocytic tumor, blue mole, nevus bleu, melanocytic nevus	[16][17][18][25]
Carcinosarcoma	no	Malignant Mullerian Mixed tumors; metaplastic carcinoma	[18]
Sarcoma botryoides	no	botryoid sarcoma, botryoid rhabdomyosarcoma; subtype of embryonal rhabdomyosarcoma	[9][16][17][18][22][27][28]
Leimyosarcoma	no	localized tumor of leukemic cells	[18][29]
Endometrioid stromal sarcoma	no	endometrial stromal sarcoma	[18][30]
Undifferentiated vaginal sarcoma			[18]
Leiomyoma	yes	fibromyoma	[6][13][16][17][18]
Genital rhabdomyoma			[16][17][18][31][32][33]
Deep angiomyoxoma			[16][17][18]
Spindle cell nodule		Vaginal Solitary Fibrous Tumor	[9][16][17][18][34]
Undifferentiated carcinoma			[16][17][18]
Small cell carcinoma	no		[16][17][18]
Carcinoid	no		[18]
Adenoid basal carcinoma			[18]
Adenosquamous carcinoma	no		[18]
Adenoma	yes		[35]
Mucinous adenocarcinoma			[18]
Squamous papilloma	yes	vaginal micropapillomatosis	[16][17][18]
Endometrioid adenocarcinoma	no		[18]
Mesonephric adenocarcinoma			[18]
Clear cell adenocarcinoma	no		[16][17][18]
Fibroepithelial polyp	yes		[16][17][18]
Squamous intraepithelial neoplasia			[16][17][18]
Genital wart	yes	Condylomata acuminata	[6][16][17][18]
Squamous cell carcinoma	no	Keratinizing, Nonkeratininzing, Basalaoid, Verrucous, Warty	[16][17][18]
Mesenchymal tumors			[18]
Alveolar soft part sarcoma			[18]
Mixed epithelial and mesenchymal Tumors			[18]
Malignant mixed Tumors resembling synovial sarcoma			[18]
Benign mixed tumors			[18]
Adenomatoid Tumor	yes		[18]
Malignant lymphoma	no		[18]
Granulocytic sarcoma			[18]
Fibroepithelial polyp	yes		[6][17]
Verrucous carcinoma	no		[9]
Squamotransitional cell carcinoma			[9]

Other animals

Vaginal tumors also can be found in domesticated animals:

• Sarcoma botryoides
• Squamous cell carcinoma
• Condyloma acuminatum
• Squamous intraepithelial neoplasia
• Fibroepithelial polyp
• Clear-cell adenocarcinoma
• Squamous papilloma
• Leiomyoma
• Blue nevus
• Malignant melanoma
• Primitive neuroectodermal tumor
• Yolk sac tumor^[36]

See also

• Urethral caruncle
• Vaginal cysts
• Vaginal intraepithelial neoplasia

Notes

1. There are four main groups of vaginal neoplasms: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers. Tumor (American English) or tumour (British English), Latin for swelling, one of the cardinal signs of inflammation, originally meant any form of swelling, neoplastic or not. Current English, however, both medical and non-medical, uses tumor as a synonym for a neoplasm (a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears enlarged in size.Some neoplasms do not form a tumor; these include leukemia and most forms of carcinoma in situ. Tumor is also not synonymous with cancer. While cancer is by definition malignant, a tumor can be benign, precancerous, or malignant