Rs4680

In genetics, rs4680 (Val158Met) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase. The single nucleotide substitution between G--> A results in an amino acid change from valine to methionine at codon 158.

SNP: rs4680
Name(s)	Val158Met, Val108/158Met, G1947A
Gene	COMT
Chromosome	22
Region	Exon 3
External databases
Ensembl	Human SNPView
dbSNP	4680
HapMap	4680
SNPedia	4680
AlzGene	Meta-analysis Overview
SzGene	Meta-analysis Overview

The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour.

The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the SzGene database shows no or very little effect.^[1]

Several personality genetics studies have examined the association of the polymorphism with personality traits including extroversion, risk aversion, and novelty seeking.^{[2][3][4][5][6]}