Valencene synthase

Valencene synthase (EC 4.2.3.73) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (valencene-forming).^[1] It is a terpene cyclase enzyme responsible for the biosynthesis of valencene, a sesquiterpene, using farnesyl pyrophosphate as its substrate. The first such enzyme was isolated using orange cDNA.^[2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate ${\displaystyle \rightleftharpoons }$ (+)-valencene + diphosphate

Valencene synthase
Identifiers
EC no.	4.2.3.73
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The recombinant enzyme from Vitis vinifera forms (+)-valencene and (-)-7-epi-α-selinene.