Valerie Hu

Valerie Wailin Hu is a professor of biochemistry and molecular biology at George Washington University, where she studies autism biomarkers.^[1]

Valerie Wailin Hu
Alma mater	University of Hawaiʻi, California Institute of Technology
Known for	Autism-related research
Children	One son
Scientific career
Fields	Biochemistry, biological psychiatry, functional genomics
Institutions	George Washington University Medical School
Thesis	Structure-function studies on cytochrome c oxidase. An investigation into the nature of the metal sites in cytochrome c oxidase using x-ray absorption spectroscopy. An investigation into the lipid factors affecting protein activity and respiratory control in reconstituted cytochrome c oxidase membranes. (1978)

Education

Hu has a bachelor's degree from the University of Hawaiʻi (1972) and a PhD from Caltech (1977);^[2] she conducted postdoctoral research into membrane biochemistry and immunology at the University of California, Los Angeles.^[3]

Research

In her research, she classified autistic children into subgroups based on their Autism Diagnostic Interview-Revised scores, and, as a result, found single nucleotide polymorphisms which, she says, could allow autism to be diagnosed with over 98% accuracy.^[4][5] Specifically, Hu's research has demonstrated that levels of two proteins produced by genes which showed changes in DNA methylation were reduced in the brains of autistic children relative to controls. Based on this finding, Hu has proposed that the use of drugs which block the chemical tagging of these genes may be a useful treatment for autism.^[6][7][8] An additional topic of Hu's research has been her discovery that the gene RORA that may be under positive regulation by androgens, leading to a buildup of additional testosterone which may contribute to the male bias of autism.^{[9][10][11][12]}