Valine N-monooxygenase

Valine N-monooxygenase (EC 1.14.13.118, CYP79D1, CYP79D2) is an enzyme with systematic name L-valine,NADPH:oxygen oxidoreductase (N-hydroxylating).^[1][2] This enzyme catalyses the following chemical reaction

L-valine + 2 O₂ + 2 NADPH + 2 H⁺ ${\displaystyle \rightleftharpoons }$ (E)-2-methylpropanal oxime + 2 NADP⁺ + CO₂ + 3 H₂O (overall reaction)

(1a) L-valine + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ N-hydroxy-L-valine + NADP⁺ + H₂O

(1b) N-hydroxy-L-valine + O2 + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ N,N-dihydroxy-L-valine + NADP⁺ + H₂O

(1c) N,N-dihydroxy-L-valine ${\displaystyle \rightleftharpoons }$ (E)-2-methylpropanal oxime + CO₂ + H₂O (spontaneous reaction)

Valine N-monooxygenase
Identifiers
EC no.	1.14.13.118
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Valine N-monooxygenase is a heme-thiolate protein (P-450).