Top Qs
Timeline
Chat
Perspective
Vesamicol
Chemical compound From Wikipedia, the free encyclopedia
Remove ads
Vesamicol is an experimental drug, acting presynaptically by inhibiting acetylcholine (ACh) uptake into synaptic vesicles and reducing its release.[1] Vesamicol may have applications for the treatment of adenocarcinoma in situ of the lung.[2]
Remove ads
Mechanism of action
Vesamicol can be broadly categorized as a cholinergic physiological antagonist, because it reduces the apparent activity of cholinergic neurons, but does not act at the postsynaptic ACh receptor. Vesamicol causes a non-competitive and reversible block of the intracellular transporter VAChT responsible for carrying newly synthesized ACh into secretory vesicles in the presynaptic nerve terminal. This transport process is driven by a proton gradient between cell organelles and the cytoplasm. Blocking of acetylcholine loading leads to empty vesicles fusing with neuron membranes, decreasing ACh release.[3]
Remove ads
References
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads