Vesatolimod

Vesatolimod (GS-9620) is an antiviral drug developed by Gilead Sciences, which acts as a potent and selective agonist of Toll-like receptor 7 (TLR7), a receptor involved in the regulation of the immune system. It is used to stimulate the immune system, which can increase its ability to combat chronic viral infections. Vesatolimod is in clinical trials to determine whether it is safe and effective in patients with Hepatitis B and HIV/AIDS,^[1][2] and has also shown activity against other viral diseases such as norovirus and enterovirus 71.^[3][4]

Vesatolimod

Identifiers
IUPAC name 4-amino-2-butoxy-8-{[3-(pyrrolidin-1-ylmethyl)phenyl]methyl}-5,7-dihydropteridin-6-one
CAS Number	1228585-88-3
PubChem CID	46241268
DrugBank	DB12687
ChemSpider	27289075
UNII	O8M467C50G
KEGG	D11003
ChEMBL	ChEMBL2424780
CompTox Dashboard (EPA)	DTXSID40153741
Chemical and physical data
Formula	C22H30N6O2
Molar mass	410.522 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCOC1=NC(=C2C(=N1)N(CC(=O)N2)CC3=CC=CC(=C3)CN4CCCC4)N
InChI InChI=1S/C22H30N6O2/c1-2-3-11-30-22-25-20(23)19-21(26-22)28(15-18(29)24-19)14-17-8-6-7-16(12-17)13-27-9-4-5-10-27/h6-8,12H,2-5,9-11,13-15H2,1H3,(H,24,29)(H2,23,25,26) Key:VFOKSTCIRGDTBR-UHFFFAOYSA-N

See also

• Imiquimod
• Motolimod