Vitamin D binding protein domain III

In molecular biology, Vitamin D binding protein domain III protein domain is predominantly found in Vitamin D binding proteins (DBP). Vitamin D-binding protein (DBP)(also referred to as Gc-globulin) is synthesized primarily in the liver. This entry outlines the domain III of DBP. Domain III (amino acid 379–458) is G-actin binding region located in the C-terminal. Domain (amino acids 373 to 403). This protein is found ubiquitously in vivo in significant quantities and can be detected in all fluid compartments.^[1] During acute phase inflammatory response, DBP levels tend to increase.

VitD-bind_III
crystal structure of uncomplexed vitamin d-binding protein
Identifiers
Symbol	VitD-bind_III
Pfam	PF09164
Pfam clan	CL0282
InterPro	IPR015247
SCOP2	1kxp / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Function

DBP has several functions. More precisely, domain III has the specific function of being an extracellular scavenger for G-actin released from necrotic cells at sites of tissue injury.^[1]

Structure

DBP domain III has a multihelical structure. It is required for formation of an actin 'clamp', allowing the protein to bind to actin.^[2] This protein is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.