Herpes simplex virus protein vmw65

Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor)^[2] is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses.^[3][4]

Alpha trans-inducing protein (Alpha-TIF)
Structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.[1]
Identifiers
Symbol	Alpha_TIF
Pfam	PF02232
InterPro	IPR003174
SMART	SM00814
SCOP2	16vp / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 16vp​

VP16 is a strong transactivator^[5] and is often used in Y2H systems as the activation domain of the system.^[6]