Pituitary-specific positive transcription factor 1

POU class 1 homeobox 1, also known as pituitary-specific positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a transcription factor for growth hormone encoded by the gene POU1F1.^[5][6]

POU1F1
Identifiers
Aliases	POU1F1, CPHD1, GHF-1, PIT1, POU1F1a, Pit-1, POU class 1 homeobox 1
External IDs	OMIM: 173110; MGI: 97588; HomoloGene: 259; GeneCards: POU1F1; OMA:POU1F1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p11.2 Start 87,259,404 bp[1] End 87,276,584 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C1.3|16 37.25 cM Start 65,317,397 bp[2] End 65,331,891 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary muscle of thigh striated muscle tissue skeletal muscle tissue gastrocnemius muscle Brodmann area 9 right uterine tube mucosa of transverse colon right coronary artery Top expressed in female urethra anterior pituitary embryo pars distalis of adenohypophysis bone marrow duodenum urinary bladder ovary More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding transcription corepressor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding DNA-binding transcription factor activity transcription factor binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex chromatin Biological process negative regulation of cell population proliferation somatotropin secreting cell development adenohypophysis development positive regulation of inositol trisphosphate biosynthetic process regulation of insulin-like growth factor receptor signaling pathway pituitary gland development regulation of transcription, DNA-templated cell fate specification B cell differentiation positive regulation of cell population proliferation positive regulation of transcription, DNA-templated determination of adult lifespan positive regulation of transcription by RNA polymerase II positive regulation of multicellular organism growth nuclear transport negative regulation of transcription by RNA polymerase II somatotropin secreting cell differentiation transcription, DNA-templated transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5449 18736 Ensembl ENSG00000064835 ENSMUSG00000004842 UniProt P28069 Q00286 RefSeq (mRNA) NM_001122757 NM_000306 NM_008849 NM_001362468 RefSeq (protein) NP_000297 NP_001116229 NP_032875 NP_001349397 Location (UCSC) Chr 3: 87.26 – 87.28 Mb Chr 16: 65.32 – 65.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

PIT1 is part of the POU family of transcription factors.^[7] It is expressed by somatotrophic cells,^[8] as well as thyrotrophs^[9] and lactotrophs^[10] of the anterior pituitary gland. It contains a C-terminal domain for transactivation.^[9] Another domain is DNA binding—its C-terminal portion is homologous to the homeodomain consensus,^[8] common to many genes involved in development, while the other portion is POU specific, affords PIT1 specificity in its transcriptional activation of the prolactin and growth hormone genes and is involved in protein-protein interactions.^[9] Activity on thyroid stimulating hormone-beta expression is also known for PIT1.^[9]

Interactions

Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2^[11] and PITX1.^[12]