VqmR sRNA

VqmR small RNA was discovered in Vibrio cholerae, a bacterium which can cause cholera, using differential RNA sequencing (sRNA-seq) under conditions of low and high cell density which were being used to study quorum sensing (QS).^[1] QS controls virulence and biofilm formation in Vibrio cholerae; it has been shown previously that it is directed by the Qrr sRNAs.^[2][3] VqmR has been shown to repress the expression of multiple mRNAs including the rtx (repeats in toxin) toxin genes and the vpsT , which is required for biofilm formation. In fact, VqmR which is highly conserved in vibrionaceae, was shown to strongly inhibit biofilm formation by repressing the vpsT gene; it could be the link between biofilm formation and QS.^[1]

VqmR sRNA
Predicted secondary structure and sequence conservation of VqmR small RNA
Identifiers
Rfam	RF02834
Other data
Domain(s)	Bacteria
GO	GO:0042710 , GO:0040033 , GO:0003729
SO	SO:0000370
PDB structures	PDBe