WAY-214156

WAY-214156
Identifiers
	IUPAC name 2,8-Dihydroxy-6H-dibenzo[c,h]chromene-4,12-dicarbonitrile;
CAS Number	1007853-40-8;
PubChem CID	11358924;
ChemSpider	9533851;
UNII	EDB7R887G3;
Chemical and physical data
Formula	C19H10N2O3
Molar mass	314.300 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1C2=C(C=CC(=C2)O)C3=C(O1)C4=C(C=C(C=C4C#N)O)C(=C3)C#N;
	InChI InChI=1S/C19H10N2O3/c20-7-10-5-17-15-2-1-13(22)4-12(15)9-24-19(17)18-11(8-21)3-14(23)6-16(10)18/h1-6,22-23H,9H2; Key:UGZYFAJTTRGNOX-UHFFFAOYSA-N;

WAY-214156 is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the ERβ.^[1]^[2] It is 100-fold selective for the ERβ over the ERα with an IC₅₀ of 4.2 nM (compare to estradiol with IC₅₀ values of ~3–4 nM for both the ERα and ERβ).^[1] The drug is less selective for the ERβ than is prinaberel (ERB-041, WAY-202041), another selective ERβ agonist, but is more potent in comparison.^[1] WAY-214156 may produce anti-inflammatory effects via the ERβ and has been proposed as a potential treatment for inflammatory conditions such as rheumatoid arthritis.^[1]^[3]

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