WDTC1

WDTC1 ("Adipose") is a gene associated with obesity.^[1][2][3]

WD and tetratricopeptide repeats 1
Identifiers
Symbol	WDTC1
NCBI gene	23038
HGNC	29175
RefSeq	NM_015023
UniProt	Q8N5D0
Other data
Locus	Chr. 1 p35.3
Search for Structures Swiss-model Domains InterPro

WDTC1 is a gene that codes for a protein acting as a suppressor in lipid accumulation. WDTC1 protein consists of seven WD40 domains, three transient receptor potential channel protein-protein interaction domains, DDB1 binding elements, and a prenylated C-terminus.^[4] Reduced expression or disruption of WDTC1 gene is associated with obesity, increased triglyceride accumulation, and adipogenesis. WDTC1 is a factor in a complex composed of DDB1, CUL4, and ROC1 that restricts transcription in adipogenesis. ^[5]

Model organisms

Studies of phenotype of mice showed that having a loss of an allele resulted in obesity and poor metabolic profiles. Transgenic expression of the WDTC1 gene in mice showed the opposite effect with mice having less adipose.^[6]