WS-23

WS-23 (methyl diisopropyl propionamide, 2-isopropyl-N,2,3-trimethylbutanamide) is a chemical compound which acts as an activator (opener) of the so-called "menthol receptor", the TRPM8 calcium channel, though with relatively low affinity and it may also act at other targets.^[1][2] It produces a similar cooling effect to menthol, and is commonly used as an ingredient of vape liquid for e-cigarettes.^[3][4]

WS-23

Identifiers
IUPAC name N,2,3-trimethyl-2-propan-2-ylbutanamide
CAS Number	51115-67-4
PubChem CID	65300
IUPHAR/BPS	2474
ChemSpider	58789
UNII	6QOP5A9489
ChEBI	CHEBI:169004
CompTox Dashboard (EPA)	DTXSID40199124
ECHA InfoCard	100.051.778
Chemical and physical data
Formula	C10H21NO
Molar mass	171.284 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)C(C)(C(C)C)C(=O)NC
InChI InChI=1S/C10H21NO/c1-7(2)10(5,8(3)4)9(12)11-6/h7-8H,1-6H3,(H,11,12) Key:RWAXQWRDVUOOGG-UHFFFAOYSA-N