XOL-1 Switch protein N-terminal domain

In molecular biology, Xol-1 is a protein domain, also named the Switch protein, is essentially a sex-determining protein. This entry focuses on the N-terminal domain of Xol-1. Xol-1, the master switch gene controlling sex-determination system and dosage compensation. This protein is normally expressed in males, where it promotes male development and prevents dosage compensation.^[1]

Xol-1_N
crystal structure of xol-1
Identifiers
Symbol	Xol-1_N
Pfam	PF09108
Pfam clan	CL0329
InterPro	IPR015192
SCOP2	1mg7 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Function

The function of the Xol-1 protein is to act as a primary sex-determining factor that promotes sexual differentiation. It is required for proper sexual differentiation and male viability. High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear.^[2]

Structure

The protein adopts a secondary structure consisting of five alpha helices and six antiparallel beta sheets. The fold of this family is similar to that found in ribosomal protein S5 domain 2-like.^[2] The active site of the enzyme is found at the interface between this domain and the C-terminal GHMP-like domain.