8-hydroxyfuranocoumarin 8-O-methyltransferase

8-hydroxyfuranocoumarin 8-O-methyltransferase (EC 2.1.1.70, furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, xanthotoxol 8-O-methyltransferase, XMT, SAM:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase, xanthotoxol methyltransferase, xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine-xanthotoxol O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction)

(2) S-adenosyl-L-methionine + xanthotoxol ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + xanthotoxin

8-hydroxyfuranocoumarin 8-O-methyltransferase
Identifiers
EC no.	2.1.1.70
CAS no.	67339-13-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

8-hydroxyfuranocoumarin 8-O-methyltransferase converts xanthotoxol into xanthotoxin.