YceI protein domain

In molecular biology, Yce-I protein domain is a putative periplasmic protein. This entry represents the lipid-binding protein YceI from Escherichia coli ^[1] and the polyisoprenoid-binding protein TTHA0802 from Thermus thermophilus.^[2] Its role is to help aid the biosynthesis of isoprenoid, an important molecule found in all living organisms.

YceI
Crystal structure of the polyisoprenoid-binding protein, TT1927B, from Thermus thermophilus hb8
Identifiers
Symbol	YceI
Pfam	PF04264
InterPro	IPR007372
SCOP2	1uf6 / SCOPe / SUPFAM
OPM superfamily	101
OPM protein	3hpe
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Structure

Both of these proteins share a common domain with an 8-stranded beta-barrel fold. This resembles the lipocalin fold, although no sequence homology exists with lipocalins. In TTHA0802, the protein binds the polyisoprenoid chain within the pore of the barrel via hydrophobic interactions.^[2] Sequence homologues of this core structure are present in a wide range of bacteria and archaea.

Function

The crystal structures suggests that this family of proteins plays an important role in isoprenoid quinone metabolism or in transport or storage. In both cases, the protein is a homodimer, each monomer being characterized by a lipocalin fold.^[2]