Z18 small nucleolar RNA

Z18 small nucleolar RNA (also known as SNORD74 and U74) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. Z18 snoRNA belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^[1]

Small nucleolar RNA SNORD74
Predicted secondary structure and sequence conservation of SNORD74
Identifiers
Symbol	SNORD74
Alt. Symbols	snoZ18; Z18
Rfam	RF00284
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe

See also

• Z6 small nucleolar RNA
• Z12 small nucleolar RNA
• Z30 small nucleolar RNA