Z3517967757

Z3517967757
Clinical data
Other names	Z7757
Identifiers
	IUPAC name 4-[1-(1-pyrimidin-2-ylethyl)piperidin-3-yl]phenol;
CAS Number	2817502-85-3 ;
PubChem CID	167949972;
Chemical and physical data
Formula	C17H21N3O
Molar mass	283.375 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C1=NC=CC=N1)N2CCCC(C2)C3=CC=C(C=C3)O;
	InChI InChI=1S/C17H21N3O/c1-13(17-18-9-3-10-19-17)20-11-2-4-15(12-20)14-5-7-16(21)8-6-14/h3,5-10,13,15,21H,2,4,11-12H2,1H3; Key:JDCMEPNJYDYSCB-UHFFFAOYSA-N;

Z3517967757, or simply Z7757, is a 3-phenylpiperidine derivative which acts as an agonist at the 5-HT₂ family of serotonin receptors, first reported in 2024. It can also be viewed as a ring-restrained phenethylamine.^[1] It has strongest activity at the 5-HT_2A receptor and lower affinity at the 5-HT_2B and 5-HT_2C receptors. However, it has been reported to have excellent selectivity for the 5-HT_2A receptor, with no agonistic activity at the 5-HT_2B and 5-HT_2C receptors.^[1] The drug was developed using in silico modelling to dock a large library of compounds against a 5-HT_2A receptor model generated by the artificial intelligence program AlphaFold, and then synthesised and tested in the laboratory to confirm activity. It has two stereogenic centers and four possible isomers, but has only been tested as a racemic mixture.^[2]^[3]^[4]

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