Z583

Z583 (GLXC-26150) is a chemical compound which acts as a potent and highly selective inhibitor of JAK3, and was developed for the treatment of rheumatoid arthritis.^{[1][2][3][4][5]}

Z583

Identifiers
IUPAC name N-[3-[[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrazolo[3,4-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide
CAS Number	2412569-41-4
PubChem CID	146478990
Chemical and physical data
Formula	C21H22N8O2
Molar mass	418.461 g·mol−1
3D model (JSmol)	Interactive image
SMILES COCCN1C=C(C=N1)NC2=NC=C3C=NN(C3=N2)CC4=CC(=CC=C4)NC(=O)C=C
InChI InChI=1S/C21H22N8O2/c1-3-19(30)25-17-6-4-5-15(9-17)13-29-20-16(11-24-29)10-22-21(27-20)26-18-12-23-28(14-18)7-8-31-2/h3-6,9-12,14H,1,7-8,13H2,2H3,(H,25,30)(H,22,26,27) Key:BOBFKXIKGHTPJB-UHFFFAOYSA-N

See also

• Ritlecitinib
• Tofacitinib