Zinc-activated ion channel

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.^[3]

ZACN
Identifiers
Aliases	ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel
External IDs	OMIM: 610935; HomoloGene: 52296; GeneCards: ZACN; OMA:ZACN - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,071,961 bp[1] End 76,083,666 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe Brodmann area 9 anterior cingulate cortex anterior pituitary mucosa of transverse colon prefrontal cortex hypothalamus apex of heart amygdala n/a More reference expression data BioGPS n/a
Gene ontology Molecular function extracellular ligand-gated ion channel activity zinc ion binding ligand-gated ion channel activity ion channel activity serotonin-gated cation-selective channel activity transmembrane signaling receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane neuron projection synapse Biological process response to zinc ion ion transport signal transduction ion transmembrane transport serotonin receptor signaling pathway chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 353174 n/a Ensembl ENSG00000186919 n/a UniProt Q401N2 n/a RefSeq (mRNA) NM_180990 n/a RefSeq (protein) NP_851321 n/a Location (UCSC) Chr 17: 76.07 – 76.08 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.^[3][4] The endogenous ligand for ZAC is thought to be Zn²⁺, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.^[3]