Zinc finger homeobox 2

Zinc finger homeobox 2 is a protein that in humans is encoded by the ZFHX2 gene.^[5] It has been implicated in pain insensitivity.^[6]

ZFHX2
Identifiers
Aliases	ZFHX2, ZFH-5, ZNF409, ZFH5, MARSIS, zinc finger homeobox 2
External IDs	OMIM: 617828; MGI: 2686934; HomoloGene: 52657; GeneCards: ZFHX2; OMA:ZFHX2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 23,520,857 bp[1] End 23,556,192 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 55,297,719 bp[2] End 55,329,781 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell sperm testicle left testis right testis lateral nuclear group of thalamus sural nerve right hemisphere of cerebellum right frontal lobe primary visual cortex Top expressed in superior frontal gyrus neural layer of retina primary visual cortex ventricular zone genital tubercle urethra cerebellar cortex male urethra neural tube dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding zinc ion binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus Biological process adult behavior regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated regulation of sensory perception of pain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85446 239102 Ensembl ENSG00000136367 ENSMUSG00000040721 UniProt Q9C0A1 Q2MHN3 RefSeq (mRNA) NM_033400 NM_001039198 RefSeq (protein) NP_207646 NP_001034287 Location (UCSC) Chr 14: 23.52 – 23.56 Mb Chr 14: 55.3 – 55.33 Mb PubMed search [3] [4]
Wikidata
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