Zinc finger protein ZFPM1

Zinc finger protein ZFPM1 also known as friend of GATA protein 1 (FOG-1) is a protein that in humans is encoded by the ZFPM1 gene.^[5] It is a cofactor of the GATA1 transcription factor.

ZFPM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XU7
Identifiers
Aliases	ZFPM1, FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A, zinc finger protein, FOG family member 1
External IDs	OMIM: 601950; MGI: 1095400; HomoloGene: 7606; GeneCards: ZFPM1; OMA:ZFPM1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.2 Start 88,453,280 bp[1] End 88,537,031 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 123,008,880 bp[2] End 123,063,990 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of ileum nasal epithelium pylorus cardia parotid gland ventral tegmental area subthalamic nucleus external globus pallidus vena cava Top expressed in tibiofemoral joint fetal liver hematopoietic progenitor cell left lobe of liver epithelium of stomach pyloric antrum internal carotid artery external carotid artery spleen duodenum human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription factor binding metal ion binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm transcription regulator complex transcription repressor complex nucleoplasm nucleus Biological process megakaryocyte development megakaryocyte differentiation negative regulation of mast cell differentiation negative regulation of fat cell differentiation regulation of transcription, DNA-templated homeostasis of number of cells ventricular septum morphogenesis outflow tract morphogenesis platelet formation blood coagulation cardiac muscle tissue morphogenesis negative regulation of transcription by RNA polymerase II negative regulation of protein binding transcription, DNA-templated regulation of chemokine production atrial septum morphogenesis heart development atrioventricular valve morphogenesis granulocyte differentiation embryonic hemopoiesis regulation of definitive erythrocyte differentiation T-helper cell lineage commitment primitive erythrocyte differentiation mitral valve formation tricuspid valve formation definitive erythrocyte differentiation positive regulation of transcription by RNA polymerase II erythrocyte differentiation regulation of megakaryocyte differentiation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 161882 22761 Ensembl ENSG00000179588 ENSMUSG00000049577 UniProt Q8IX07 O35615 RefSeq (mRNA) NM_153813 NM_009569 RefSeq (protein) NP_722520 NP_033595 Location (UCSC) Chr 16: 88.45 – 88.54 Mb Chr 8: 123.01 – 123.06 Mb PubMed search [3] [4]
Wikidata
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