ZK-93426

ZK-93426 (ethyl-5-isopropoxy-4-methyl-β-carboline-3-carboxylate) is a drug from the β-carboline family. It acts as a weak partial inverse agonist of benzodiazepine receptors,^[1] meaning that it causes the opposite effects to the benzodiazepine class of drugs and has anxiogenic properties,^[2] although unlike most benzodiazepine antagonists it is not a convulsant and actually has weak anticonvulsant effects.^[3] In human tests it produced alertness, restlessness and feelings of apprehension,^{[clarification needed]} and reversed the effect of the benzodiazepine lormetazepam.^[4][5] It was also shown to produce nootropic effects^[6][7] and increased release of acetylcholine.^[8][9]

ZK-93426

Names
Preferred IUPAC name Ethyl 4-methyl-5-[(propan-2-yl)oxy]-9H-pyrido[3,4-b]indole-3-carboxylate
Other names ZK-93426 Ethyl 5-isopropoxy-4-methyl-9H-β-carboline-3-carboxylate
Identifiers
CAS Number	89592-45-0 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL1271047 N
ChemSpider	103086 N
IUPHAR/BPS	4347
PubChem CID	115210
CompTox Dashboard (EPA)	DTXSID401008889
InChI InChI=1S/C18H20N2O3/c1-5-22-18(21)17-11(4)15-13(9-19-17)20-12-7-6-8-14(16(12)15)23-10(2)3/h6-10,20H,5H2,1-4H3 N Key: VMDUABMKBUKKPG-UHFFFAOYSA-N N InChI=1/C18H20N2O3/c1-5-22-18(21)17-11(4)15-13(9-19-17)20-12-7-6-8-14(16(12)15)23-10(2)3/h6-10,20H,5H2,1-4H3 Key: VMDUABMKBUKKPG-UHFFFAOYAG
SMILES CCOC(=O)C1=NC=C2C(=C1C)C3=C(N2)C=CC=C3OC(C)C
Properties
Chemical formula	C18H20N2O3
Molar mass	312.369 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

See also

• Substituted β-carboline
• ZK-93423