CNBP

Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene.^[5][6][7]

CNBP
Identifiers
Aliases	CNBP, CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9, CCHC-type zinc finger nucleic acid binding protein
External IDs	OMIM: 116955; MGI: 88431; HomoloGene: 2567; GeneCards: CNBP; OMA:CNBP - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 129,167,827 bp[1] End 129,183,922 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 87,819,597 bp[2] End 87,828,088 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis thoracic diaphragm biceps brachii Skeletal muscle tissue of biceps brachii oocyte Achilles tendon gastrocnemius muscle seminal vesicula parotid gland tail of epididymis Top expressed in otic placode saccule otic vesicle primitive streak endothelial cell of lymphatic vessel abdominal wall hair follicle vestibular sensory epithelium triceps brachii muscle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding zinc ion binding DNA-binding transcription factor activity metal ion binding DNA binding single-stranded DNA binding single-stranded RNA binding RNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific mRNA binding translation regulator activity Cellular component nucleus cytoplasm endoplasmic reticulum cytosol Biological process regulation of transcription, DNA-templated cholesterol biosynthetic process transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated positive regulation of cell population proliferation negative regulation of transcription by RNA polymerase II positive regulation of cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7555 12785 Ensembl ENSG00000169714 ENSMUSG00000030057 UniProt P62633 P53996 RefSeq (mRNA) NM_003418 NM_001127192 NM_001127193 NM_001127194 NM_001127195 NM_001127196 NM_001109745 NM_001109746 NM_013493 NM_001347325 NM_001355195 RefSeq (protein) NP_001120664 NP_001120665 NP_001120666 NP_001120667 NP_001120668 NP_003409 NP_001103215 NP_001103216 NP_001334254 NP_038521 NP_001342124 Location (UCSC) Chr 3: 129.17 – 129.18 Mb Chr 6: 87.82 – 87.83 Mb PubMed search [3] [4]
Wikidata
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Function

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM]^[7]