Zatosetron

Zatosetron (LY-277,359) is a drug which acts as an antagonist at the 5HT₃ receptor^[1] It is orally active and has a long duration of action, producing antinauseant effects but without stimulating the rate of gastrointestinal transport.^[2][3] It is also an effective anxiolytic in both animal studies and human trials,^[4] although with some side effects at higher doses.^[5][6]

Zatosetron

Clinical data
ATC code	none
Identifiers
IUPAC name 5-chloro-2,2-dimethyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-1-benzofuran-7-carboxamide
CAS Number	123482-22-4 Y
PubChem CID	60763
ChemSpider	16736584
UNII	901MC95XSB
CompTox Dashboard (EPA)	DTXSID8043997
Chemical and physical data
Formula	C19H25ClN2O2
Molar mass	348.87 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1(Cc2cc(cc(c2O1)C(=O)N[C@H]3C[C@H]4CC[C@@H](C3)N4C)Cl)C
InChI InChI=1S/C19H25ClN2O2/c1-19(2)10-11-6-12(20)7-16(17(11)24-19)18(23)21-13-8-14-4-5-15(9-13)22(14)3/h6-7,13-15H,4-5,8-10H2,1-3H3,(H,21,23)/t13-,14+,15- Key:SPKBYQZELVEOLL-QDMKHBRRSA-N
NY (what is this?)  (verify)

See also

• Ondansetron
• Bemesetron
• Granisetron
• Ricasetron
• Tropanserin
• Tropisetron