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Zetekitoxin AB

Chemical compound From Wikipedia, the free encyclopedia

Zetekitoxin AB
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Zetekitoxin AB (ZTX) is a guanidine alkaloid found in the Panamanian golden frog Atelopus zeteki. It is an extremely potent neurotoxin.

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Structure

ZTX is a guanidine alkaloid. It's structurally related to saxitoxin, but with some differences. ZTX contains an isoxazolidine ring, a sulfonate group and an N-hydroxycarbamate group.[2]

Mechanism of action

ZTX is an extremely potent sodium channel blocker. It has been shown to block the voltage-gated sodium channels at picomolar concentrations. It is about 580 times more potent than saxitoxin.[2]

Toxicity

ZTX is an extremely potent neurotoxin. The LD50 of ZTX in mice is 11 μg/kg.[3]

See also

References

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