Zimlovisertib

Zimlovisertib (PF-06650833) is a drug which acts as a selective inhibitor of the enzyme Interleukin-1 receptor-associated kinase 4 (IRAK-4). It has antiinflammatory effects and has been trialed for various indications including hidradenitis suppurativa and treatment of COVID-19 infection, and while it has not been adopted into clinical use it continues to be used for research in this area.^[1][2][3]

Zimlovisertib

Identifiers
IUPAC name 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide
CAS Number	1817626-54-2
PubChem CID	118414016
DrugBank	DB15143
ChemSpider	58805665
UNII	S3F315JJXI
ChEMBL	ChEMBL4081711
Chemical and physical data
Formula	C18H20FN3O4
Molar mass	361.373 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC[C@H]1[C@H](NC(=O)[C@H]1F)COC2=NC=CC3=CC(=C(C=C32)OC)C(=O)N
InChI InChI=1S/C18H20FN3O4/c1-3-10-13(22-17(24)15(10)19)8-26-18-11-7-14(25-2)12(16(20)23)6-9(11)4-5-21-18/h4-7,10,13,15H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,15-/m0/s1 Key:JKDGKIBAOAFRPJ-ZBINZKHDSA-N

See also

• Emavusertib
• Zabedosertib