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Mantle zone

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Mantle zone
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The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.[1]

Quick Facts
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Image labeled in German, but "Mantel-zone" visible near center

It is also known as the "corona".[2]

It contains transient lymphocytes.[3]

It is the location of the lymphoma in mantle cell lymphoma.

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Pathology

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Intermediate magnification micrograph of Castleman disease showing the characteristic expansion of the mantle zone. H&E stain

Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma. Tcl-1 is expressed in the mantle zone.

References

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