Mantle zone

The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.^[1]

Mantle zone
Histology of a normal secondary lymphoid follicle, with yellow arrows pointing at the mantle zone.
Anatomical terminology [edit on Wikidata]

Image labeled in German, but "Mantel-zone" visible near center

It is also known as the "corona".^[2]

It contains transient lymphocytes.^[3]

It is the location of the lymphoma in mantle cell lymphoma.

Pathology

Intermediate magnification micrograph of Castleman disease showing the characteristic expansion of the mantle zone. H&E stain

Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma. Tcl-1 is expressed in the mantle zone.